Cellulose aerogel micro fibers for drug delivery applications

Textile engineering can offer a multi-scale toolbox via various fiber or textile fabrication methods to obtain woven nonwoven aerogels with different structural and mechanical properties overcome the current limitations of polysaccharide-based aerogels, such as poor undeveloped shaping techniques. Hereby, high viscous solution microcrystalline cellulose zinc chloride hydrate was wet spun produce mono multi-filament alcogel microfibers. Subsequently, aerogel fibers (CAF) were produced impregnated model drugs using supercritical CO 2 processes. Fibers characterized in terms morphology textural properties, thermal stability, vitro biological drug release assessments. Loaded non-loaded CAFs proved have macro-porous outer shell nano-porous inner core interconnected pore structure specific area range 100–180 m /g. The larger diameter (d ~ 235 ?m) able form knitted mesh while lower 70 formed needle punched textiles. Humidity water uptake assessments indicated that fibrous structures highly moisture absorbable non-toxic immediate profiles due open porous fibers. Finally, are propitious be further developed for biomedical applications delivery wound care. • Wet microfibers prepared by scCO drying meshes. solvent exchange impregnation an effective single-step technique loading formation. Cellulose demonstrated core-shell humidity absorbance. micro exhibited behavior besides biocompatibility.